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论文类型：期刊论文

发表时间：2008-05-12

发表刊物：TETRAHEDRON LETTERS

收录刊物：SCIE

卷号：49

期号：20

页面范围：3260-3263

ISSN号：0040-4039

关键字：reductions; aromatic carboxylic acids; borane; sodium borohydride; trimethyl borate

摘要：The reduction of hydroxyl-substituted aromatic carboxylic acid with NaBH(4)/Me(2)SO(4)/B(OMe)(3) is described. Borane is generated by the reaction of NaBH(4) with Me(2)SO(4) in THF, which is as efficient as the commercial one. B(OMe)(3) has been successfully applied to increase the reactivity and selectivity of this reaction. The optimum ratio of borane/B(OMe)(3)/acid is studied, and a variety of hydroxyl-substituted aromatic acids are reduced in good yields. (c) 2008 Elsevier Ltd. All rights reserved.