1-Naphthol Synthesis through Base-Promoted SNAr Reactions of ortho-Haloacetophenones Followed by Lewis-Acid-Catalyzed Cyclization
Release Time:2019-03-13 Hits:
Indexed by: Journal Papers
Date of Publication: 2016-05-01
Journal: ASIAN JOURNAL OF ORGANIC CHEMISTRY
Included Journals: SCIE
Volume: 5
Issue: 5
Page Number: 699-704
ISSN: 2193-5807
Key Words: 1-naphthols; aryl halides; copper catalysis; ortho-haloacetophenones; SNAr reactions
Abstract: An efficient method was developed for the synthesis of 1-naphthols through NaOtBu-promoted SNAr reaction of ortho-haloacetophenones followed by Lewis acid CuI-catalyzed intramolecular condensation and isomerization. 1-Naphthol derivatives were obtained in satisfactory yields from aryl bromide and aryl iodide substrates.