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1-Naphthol Synthesis through Base-Promoted SNAr Reactions of ortho-Haloacetophenones Followed by Lewis-Acid-Catalyzed Cyclization

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Indexed by:Journal Papers

Date of Publication:2016-05-01

Journal:ASIAN JOURNAL OF ORGANIC CHEMISTRY

Included Journals:SCIE

Volume:5

Issue:5

Page Number:699-704

ISSN No.:2193-5807

Key Words:1-naphthols; aryl halides; copper catalysis; ortho-haloacetophenones; SNAr reactions

Abstract:An efficient method was developed for the synthesis of 1-naphthols through NaOtBu-promoted SNAr reaction of ortho-haloacetophenones followed by Lewis acid CuI-catalyzed intramolecular condensation and isomerization. 1-Naphthol derivatives were obtained in satisfactory yields from aryl bromide and aryl iodide substrates.

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