Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2015-04-17

Journal: JOURNAL OF ORGANIC CHEMISTRY

Included Journals: Scopus、PubMed、EI、SCIE

Volume: 80

Issue: 8

Page Number: 3998-4002

ISSN: 0022-3263

Abstract: An efficient method for the synthesis of isoquinolones through base (KOBu)-Bu-t-promoted SNAr reaction of 2-halobenzonitriles with ketones followed by Lewis acid Cu(OAc)(2)-catalyzed cyclization is described. Isoquinolone derivatives were obtained in satisfactory to good yields.