包明
个人信息Personal Information
教授
博士生导师
硕士生导师
性别:男
毕业院校:日本东北大学
学位:博士
所在单位:化工学院盘锦分院
办公地点:精细化工国家重点实验室E504
电子邮箱:mingbao@dlut.edu.cn
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Chemoselective Suzuki-Miyaura Coupling of Bromophenyl-Substituted Bromoallenes with Arylboronic Acids
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论文类型:期刊论文
发表时间:2012-06-01
发表刊物:SYNLETT
收录刊物:SCIE、Scopus
卷号:23
期号:10
页面范围:1505-1510
ISSN号:0936-5214
关键字:coupling; chemoselectivity; palladium; oxidation; addition
摘要:Developing highly chemoselective Suzuki-Miyaura coupling reactions is of great value in the synthetic chemistry. Here we report the results of palladium-catalyzed reaction of bromoallenes containing an aryl bromide moiety with arylboronic acids. It is found that the C-Br insertion exclusively takes place on bromoallene rather than on the benzene ring. Theoretical calculations demonstrate that the corresponding oxidative addition intermediate has a much lower free energy.