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An efficient transformation of primary halides into nitriles through palladium-catalyzed hydrogen transfer reaction

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Indexed by:期刊论文

Date of Publication:2015-07-07

Journal:CHEMICAL COMMUNICATIONS

Included Journals:SCIE、PubMed、Scopus

Volume:51

Issue:53

Page Number:10714-10717

ISSN No.:1359-7345

Abstract:Two-step one-pot transformation of primary halides into corresponding nitriles is successfully achieved. Nucleophilic substitution of primary halides with sodium azide and subsequent palladium-catalyzed hydrogen transfer proceeds smoothly in the presence of sterically bulky ligand dicyclohexyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphine (XPhos) in acetone to produce nitriles in satisfactory to good yields.

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