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Indexed by:Journal Papers
Date of Publication:2019-09-15
Journal:METHODS
Included Journals:SCIE、PubMed
Volume:168
Page Number:24-28
ISSN No.:1046-2023
Key Words:Fluorescent probe; Metal-detector; Nickel; Cell imaging; Mitochondria
Abstract:In this paper, we unveil a new highly selective and sensitive mito-tracker (NiP) for Ni2+ detection. NiP itself held very weak fluorescence and exhibited a high selectivity (>= 160-fold) toward Ni2+ over other metal ions, with a limit of detection of 21.6 nmol. We demonstrate the practicality of NiP for the rapid determination of Ni2+ levels in mitochondria of living cells. This approach offers advantages by being fast, simple and low cost.
