Release Time:2020-02-15  Hits:

Indexed by: Journal Papers

Date of Publication: 2019-09-15

Journal: METHODS

Included Journals: PubMed、SCIE

Volume: 168

Page Number: 24-28

ISSN: 1046-2023

Key Words: Fluorescent probe; Metal-detector; Nickel; Cell imaging; Mitochondria

Abstract: In this paper, we unveil a new highly selective and sensitive mito-tracker (NiP) for Ni2+ detection. NiP itself held very weak fluorescence and exhibited a high selectivity (>= 160-fold) toward Ni2+ over other metal ions, with a limit of detection of 21.6 nmol. We demonstrate the practicality of NiP for the rapid determination of Ni2+ levels in mitochondria of living cells. This approach offers advantages by being fast, simple and low cost.