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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工
办公地点：大连理工大学西部校区F-206
联系方式：fanjl@dlut.edu.cn
电子邮箱：fanjl@dlut.edu.cn
扫描关注
An estrogen receptor targeted ruthenium complex as a two-photon photodynamic therapy agent for breast cancer cells
点击次数：53
论文类型：期刊论文
发表时间：2018-06-28
发表刊物：CHEMICAL COMMUNICATIONS
收录刊物：SCIE
卷号：54
期号：51
页面范围：7038-7041
ISSN号：1359-7345
摘要：In this study, we reported a tamoxifen modified Ru(ii) polypyridyl complex (Ru-tmxf) as an estrogen receptor (ER) targeted photosensitizer. Ru-tmxf displays enhanced cellular uptake and PDT efficiency toward breast cancer cells with high ER expression due to the specific targeting of tamoxifen to ER and finally localizes in lysosomes. Moreover, Ru-tmxf can be activated by two-photon excitation, generating O-1(2) to damage lysosomes and result in cell death.