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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工
办公地点：大连理工大学西部校区F-206
联系方式：fanjl@dlut.edu.cn
电子邮箱：fanjl@dlut.edu.cn
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Mito-targeted "turn-on" fluorescent probe for nickel (II) detection
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论文类型：期刊论文
发表时间：2019-09-15
发表刊物：METHODS
收录刊物：SCIE、PubMed
卷号：168
页面范围：24-28
ISSN号：1046-2023
关键字：Fluorescent probe; Metal-detector; Nickel; Cell imaging; Mitochondria
摘要：In this paper, we unveil a new highly selective and sensitive mito-tracker (NiP) for Ni2+ detection. NiP itself held very weak fluorescence and exhibited a high selectivity (>= 160-fold) toward Ni2+ over other metal ions, with a limit of detection of 21.6 nmol. We demonstrate the practicality of NiP for the rapid determination of Ni2+ levels in mitochondria of living cells. This approach offers advantages by being fast, simple and low cost.