|
个人信息Personal Information
教授
博士生导师
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工
办公地点：大连理工大学西部校区F-206
联系方式：fanjl@dlut.edu.cn
电子邮箱：fanjl@dlut.edu.cn
扫描关注
Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells
点击次数：
论文类型：期刊论文
发表时间：2011-02-21
发表刊物：ORGANIC & BIOMOLECULAR CHEMISTRY
收录刊物：SCIE、EI、PubMed、Scopus
卷号：9
期号：4
页面范围：980-983
ISSN号：1477-0520
摘要：A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by (1)H NMR, mass spectrometry analysis and Gaussian calculations.