Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2012-10-01

Journal: TRANSFUSION AND APHERESIS SCIENCE

Included Journals: Scopus、PubMed、SCIE

Volume: 47

Issue: 2

Page Number: 159-165

ISSN: 1473-0502

Key Words: Bilirubin; beta-Cyclodextrin; Polyethyleneimine; Water-soluble adsorbent

Abstract: A water-soluble adsorbent was developed for removing bilirubin from the plasma of hyper-bilirubinemia patient. The adsorbent was synthesized by grafting beta-cyclodextrin (beta-CD) to branched polyethyleneimine (PEI) matrix. The resulting beta-CD-PEI polymer had an average molecular weight of 163.7 kD, and it contained 56.3 beta-CD functional groups. In beta-CD-PEI-spiked dialysis, 35.8% of plasma bilirubin was removed, which was higher than that removed by the same concentration of bovine serum albumin. beta-CD-PEI also removed aromatic amino acids and bile acids. The results indicated that beta-CD-PEI could be an effective adsorbent for blood purification application aiming at the removal of toxins. (C) 2012 Published by Elsevier Ltd.