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发布时间：2019-03-09

论文类型：期刊论文

发表时间：2012-10-21

发表刊物：LAB ON A CHIP

收录刊物：PubMed、SCIE

卷号：12

期号：20

页面范围：4059-4062

ISSN号：1473-0197

摘要：In this paper, we present a new approach that is capable of fabricating nanochannels in a poly(methyl methacrylate) (PMMA) substrate. This method, which we call microchannel refill (MR), utilizes the refilling of glassy thermoplastics under thermal compression to reduce a microscopic channel to a nanochannel. It only has two main steps. First, a microchannel is fabricated in a PMMA substrate using normal hot embossing. Second, the microchannel is compressed under a certain temperature and pressure to obtain a nanochannel. We show that a nanochannel with a width as small as 132 nm (with a depth of 85 nm) can be easily produced by choosing the appropriate compression temperature, compression pressure, original microchannel width and original microchannel aspect ratio. Compared with most current nanochannel fabrication methods, MR is a quick, simple and cost-effective way to produce nanochannels in polymer substrates.