点击次数：

论文类型：期刊论文

发表时间：2014-01-10

发表刊物：JOURNAL OF ETHNOPHARMACOLOGY

收录刊物：SCIE、PubMed、Scopus

卷号：151

期号：1

页面范围：452-460

ISSN号：0378-8741

关键字：Traditional Chinese Medicine; Eucommia ulmoides Oliv.; Systems pharmacology; Network analysis

摘要：Ethnopharmacology relevance: Though Traditional Chinese Medicine (TCM) has long been playing a significant role in the maintenance of health for people in Asia as well as many other places, the mechanism of its action still remains ambiguous for most of the plants used in TCM, such as Eucommia ulmoides Oliv., a kind of herb that is widely used to help regulate hypertension and the immune system nowadays. However, its functioning mechanism is still unknown. Thus it is necessary to exploit the mechanism of Eucommia ulmoides Oliv.
   Methods: A systems pharmacology approach combining drug-likeness evaluation, oral bioavailability prediction, multiple drug targets prediction as well as network pharmacology techniques has been used.
   Results: This comprehensive systematic approach helps successfully to identify 41 candidate compounds contained in Eucommia ulmoides Oliv. while 39 potential targets hit by these ingredients and helps to uncover the synergistic mechanism of action on a systematic level.
   Conclusions: Our work successfully explains the mechanism of the efficiency of Eucommia ulmoides Oliv. for the treatment of hypertension and enhancing immune. These results not only provide a new insight for the understanding of the chemical and pharmacological basis of Eucommia ulmoides Oliv., but also provide an efficient way for drug discovery from herbal medicine. (C) 2013 Elsevier Ireland Ltd. All rights reserved.