Release Time:2019-03-13  Hits:

Indexed by: Journal Article

Date of Publication: 2016-04-01

Journal: IET NANOBIOTECHNOLOGY

Included Journals: EI、SCIE、PubMed

Volume: 10

Issue: 2

Page Number: 75-80

ISSN: 1751-8741

Key Words: nanofluidics; nanofabrication; plastics; optical sensors; nanosensors; biological techniques; gold; biosensors; autofluorescence fabrication methods; plastic nanoslits; plastic nanofluidic devices; biological applications; chemical applications; on-chip optical detection; gold layer; SU-8; polyethylene terephthalate; size 20 mum; size 150 mum; size 0; 8 mm; Au

Abstract: Plastic nanofluidic devices are becoming increasingly important for biological and chemical applications. However, they suffer from high auto-fluorescence when used for on-chip optical detection. In this study, the auto-fluorescence problem of plastic nanofluidic devices was remedied by newly developed fabrication methods that minimise their auto-fluorescence: one by depositing a gold (Au) layer on them, the other by making them ultra-thin. In the first method, the Au layer [minimum thickness is 40 nm on 150 m SU-8, 50 nm on 1 mm polyethylene terephthalate (PET), and 40 on 2 nm polymethyl methacrylate (PMMA)] blocks the auto-fluorescence of the polymer; in the second method, auto-fluorescence is minimised by making the chips ultra-thin, selected operating thickness of SU-8 is 20 m, for PET it is 150 m, and for PMMA it is 0.8 mm.