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Indexed by:期刊论文

Date of Publication:2016-04-01

Journal:IET NANOBIOTECHNOLOGY

Included Journals:PubMed、SCIE、EI

Volume:10

Issue:2

Page Number:75-80

ISSN No.:1751-8741

Key Words:nanofluidics; nanofabrication; plastics; optical sensors; nanosensors; biological techniques; gold; biosensors; autofluorescence fabrication methods; plastic nanoslits; plastic nanofluidic devices; biological applications; chemical applications; on-chip optical detection; gold layer; SU-8; polyethylene terephthalate; size 20 mum; size 150 mum; size 0; 8 mm; Au

Abstract:Plastic nanofluidic devices are becoming increasingly important for biological and chemical applications. However, they suffer from high auto-fluorescence when used for on-chip optical detection. In this study, the auto-fluorescence problem of plastic nanofluidic devices was remedied by newly developed fabrication methods that minimise their auto-fluorescence: one by depositing a gold (Au) layer on them, the other by making them ultra-thin. In the first method, the Au layer [minimum thickness is 40 nm on 150 m SU-8, 50 nm on 1 mm polyethylene terephthalate (PET), and 40 on 2 nm polymethyl methacrylate (PMMA)] blocks the auto-fluorescence of the polymer; in the second method, auto-fluorescence is minimised by making the chips ultra-thin, selected operating thickness of SU-8 is 20 m, for PET it is 150 m, and for PMMA it is 0.8 mm.