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Indexed by:期刊论文

Date of Publication:2016-07-01

Journal:EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Included Journals:SCIE

Issue:20

Page Number:3373-3379

ISSN No.:1434-193X

Key Words:Synthetic methods; Aromatic substitution; Nitrogen heterocycles; Thiocyanates; Sulfur

Abstract:A direct C-H thiocyanation of imidazo[1,2-a]pyridines, and a practical sequential one-pot condensation/C-H thiocyanation process, using a combination of N-chlorosuccinimide/NaSCN for the synthesis of 3-thiocyanatoimidazo[1,2-a]pyridines have been developed. The reactions are environmentally friendly, and easy to carry out. They use readily available starting materials and mild reaction conditions, show a wide functional group tolerance, and give good to excellent yields.