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Indexed by:期刊论文
Date of Publication:2016-09-15
Journal:CHEMICAL COMMUNICATIONS
Included Journals:SCIE、PubMed、Scopus
Volume:52
Issue:76
Page Number:11426-11429
ISSN No.:1359-7345
Abstract:A natural quinidine-catalyzed asymmetric chlorination of 4-substituted pyrazolones is developed, affording products with a quaternary chiral chlorine-attached carbon centre in high yield with excellent enantio-selectivity. The low catalyst loading (1 mol%), broad substrate scope, and facile and valuable transformation of the product highlight the practical utility of this process.
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