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Catalytic asymmetric construction of spiro[pyrrolidine-2,3 '-oxindole] scaffolds through chiral phosphoric acid-catalyzed 1,3-dipolar cycloaddition involving 3-amino oxindoles

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Indexed by:期刊论文

Date of Publication:2015-11-04

Journal:CHEMICAL COMMUNICATIONS

Included Journals:SCIE、PubMed、Scopus

Volume:51

Issue:85

Page Number:15510-15513

ISSN No.:1359-7345

Abstract:The catalytic asymmetric three-component 1,3-dipolar cycloaddition of 3-amino oxindoles with aldehydes and nitroolefins under the catalysis of a chiral phosphoric acid is reported. The reaction provides a facile approach to synthesize a diverse array of spiro[pyrrolidine-2,3'-oxindoles] in high yields with excellent diastereo-and enantioselectivities under mild conditions.

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