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Zinc chloride catalyzed stereoselective construction of spiropyrazolone tetrahydroquinolines via tandem [1,5]-hydride shift/cyclization sequence

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Indexed by:期刊论文

Date of Publication:2015-01-01

Journal:RSC ADVANCES

Included Journals:SCIE、EI、Scopus

Volume:5

Issue:105

Page Number:86056-86060

ISSN No.:2046-2069

Abstract:A zinc chloride catalyzed tandem 1,5-hydride shift/cyclization process to form spiropyrazolone terahydroquinoline derivatives is developed. A series of new spiropyrazolone derivatives were obtained in good to high yields with good to excellent diastereoselectivities (up to 95% yield, >95 : 5 dr). Additionally, the spiropyrazolone derivatives could be converted into the corresponding novel spriopyrazolines.

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