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Indexed by:期刊论文

Date of Publication:2014-01-01

Journal:AUSTRALIAN JOURNAL OF CHEMISTRY

Included Journals:SCIE、EI、Scopus

Volume:67

Issue:7

Page Number:1115-1118

ISSN No.:0004-9425

Abstract:A novel library of chiral guanidines featuring the tartaric acid skeleton is easily accessed with tunable steric and electronic properties. A guanidine molecule of this library with an incorporated 2,6-diisoaniline fragment was identified as a suitable promoter for the enantioselective fluorination of 1,3-dicarbonyl and alpha-cyano carbonyl compounds to furnish the fluorinated product with up to 84% ee and 99% yield using N-fluorobenzenesulfonimide (NFSI) as the fluorinating agent.