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论文类型：期刊论文

发表时间：2018-12-13

发表刊物：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

收录刊物：SCIE、Scopus

卷号：2018

期号：46

页面范围：6469-6473

ISSN号：1434-193X

关键字：Pyrazolone; Allenamide; Asymmetric catalysis; Chiral phosphoric acid; Heterocycles

摘要：We describe a new asymmetric allylic alkylation of pyrazolones, in which an all-carbon quaternary stereocenter with broad substrate scope and good enantioselectivity was generated. The asymmetric addition of pyrazolones to allenamides could be carried out under mild conditions in excellent yields with a relatively low catalyst loading. The allylic products with an enamide structure can be easily transformed to the pyrazolones with other functional groups, which provides a new approach for the asymmetric introduction of new functional groups into the pyrazolone skeleton.