羟基多溴联苯醚甲状腺激素效应的构效关系研究
Release Time:2019-03-09 Hits:
Indexed by: Conference Paper
Date of Publication: 2010-06-01
Page Number: 1-1
Key Words: HO-PBDEs;构效关系;甲状腺激素效应;配体-受体相互作用
Abstract: 羟基多溴联苯醚(HO-PBDEs)的化学结构与甲状腺激素(T3,T4)相似,能够与T4竞争结合甲状腺运载蛋白(TTR),具有甲状腺激素干扰效应。但尚无关于HO-PBDEs与甲状腺激素受体(TR)结合的系统性研究,作用机制尚不明确。本研究采用分子对
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