Release Time:2019-03-12  Hits:

Indexed by: Journal Article

Date of Publication: 2018-11-16

Journal: ORGANIC LETTERS

Included Journals: Scopus、SCIE、PubMed

Volume: 20

Issue: 22

Page Number: 7095-7099

ISSN: 1523-7060

Abstract: A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids.