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Indexed by:期刊论文

Date of Publication:2018-11-16

Journal:ORGANIC LETTERS

Included Journals:PubMed、SCIE、Scopus

Volume:20

Issue:22

Page Number:7095-7099

ISSN No.:1523-7060

Abstract:A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids.