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Indexed by:期刊论文

Date of Publication:2011-09-15

Journal:CHEMICAL ENGINEERING SCIENCE

Included Journals:Scopus、SCIE、EI

Volume:66

Issue:18

Page Number:4101-4110

ISSN No.:0009-2509

Key Words:Aerobic fermentation; Biomass biosynthesis; Bioprocess stability; Corynebacterium glutamicum; Optimisation; Periodic solutions

Abstract:This work concerns the modelling of the Corynebacterium glutamicum biosynthesis. At the beginning, the impulsive growth model of C. glutamicum under glutamate inhibition is established. According to this model, the analysis of the bioprocess stability is presented. Then, new objective functions are proposed and optimisation of C. glutamicum growth is presented. The results of the optimisation indicate that, although the growth of C glutamicum is an aerobic process, the maximum of biomass productivity occurs under controlled penetration into the area of aerobic fermentation. Analytical results presented in this work are validated by numerical simulations. (C) 2011 Elsevier Ltd. All rights reserved.