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    孙亮

    • 副教授       硕士生导师
    • 性别:男
    • 毕业院校:吉林大学
    • 学位:博士
    • 所在单位:计算机科学与技术学院
    • 学科:计算机应用技术
    • 办公地点:创新园大厦B802
    • 联系方式:15998564404
    • 电子邮箱:liangsun@dlut.edu.cn

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    An automatic motif recognition algorithm in DNA sequences based on particle swarm optimization and random projection

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    论文类型:会议论文

    发表时间:2017-01-01

    收录刊物:CPCI-S

    卷号:2017-January

    页面范围:2241-2243

    关键字:motif recognition; random projection; particle swarm optimization

    摘要:Motif recognition plays a significant role for understanding the biological meanings of sequences. In this paper, a particle swarm optimization and random projection based algorithm (PSORPS) is proposed for recognizing DNA motifs. First, noise subsequences are filtered by a random projection strategy for constructing objective space. Then the PSO is used to automatically search the motifs of DNA sequences in the constructed l-mer objective space. Finally, the operators of independent drift and associated drift are conducted on the optimization results to alleviate base deviation. The experiments are carried out on real-world biological datasets, and the results validate the effectiveness of the proposed algorithm.