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论文类型：期刊论文

发表时间：2013-11-01

发表刊物：JOURNAL OF FLUORESCENCE

收录刊物：SCIE、EI、PubMed、Scopus

卷号：23

期号：6

页面范围：1113-1120

ISSN号：1053-0509

关键字：Ruthenium complex; Luminescent probe; Nitric oxide; Luminescence detection

摘要：Nitric oxide (NO) is one of the most important intercellular signaling molecules, and plays important roles in various biological systems. In this work, a unique Ru-II complex, tris[(5-(4-methylamino-3-aminobenzylamino)-1,10-phenanthroline)] ruthenium(II) hexafluorophosphate [Ru(MAA-phen)(3)][PF6](2), has been designed and synthesized as a luminescent probe for the detection of NO in aqueous media. The complex itself is almost non-luminescent, but can specifically react with NO under the aerobic conditions to afford its highly luminescent triazole derivative in aqueous media, [Ru(MTA-phen)(3)](2+) (MTA-phen: methyl-trazolebenzylamino-1,10-phenanthroline), accompanied by a 302-fold increase in luminescence intensity at 598 nm with a 130 nm Stokes shift. The luminescence response of [Ru(MAA-phen)(3)](2+) to NO is rapid, highly specific without interferences of other reactive oxygen/nitrogen species, and highly stable against the pH changes in the range of pH 4.5-9.5. These features enable [Ru(MAA-phen)(3)](2+) to be used as a probe for the highly selective and sensitive luminescence detection of NO in weakly acidic, neutral, and weakly basic media.