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论文类型： 期刊论文

发表时间： 2017-12-01

发表刊物： DYES AND PIGMENTS

收录刊物： Scopus、SCIE、EI

卷号： 147

页面范围： 99-105

ISSN号： 0143-7208

关键字： BODIPY; Photosensitizer; Targeting; Lysosomes; Photodynamic therapy

摘要： As an indispensable organelle, lysosomes play critical role in cell digestion and are closely relate to cell death and apoptosis. Photosensitizers that target to lysosomes are extremely important to photodynamic therapy. Herein, we report an excellent BODIPY based photosensitizer MBDP for lysosome targeting NIR photosensitizer. MBDP exhibits excellent PDT efficiency with low IC50 of 0.2 mu M compared to the classical photosensitizer Ce6 (IC50 = 139 mu M). Furthermore, MBDP can localize in lysosomes of cancer cells and produce significant singlet oxygen with photoexcitation of 660 nm red light. Additionally, lysosome destruction test and photoinduce cell death assay demonstrate that MBDP-mediated PDT is able to damage the lysosome integrity severely and result in cell apoptosis and death in lysosomal related pathway. (C) 2017 Elsevier Ltd. All rights reserved.