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论文类型： 期刊论文

发表时间： 2018-06-28

发表刊物： CHEMICAL COMMUNICATIONS

收录刊物： SCIE

卷号： 54

期号： 51

页面范围： 7038-7041

ISSN号： 1359-7345

摘要： In this study, we reported a tamoxifen modified Ru(ii) polypyridyl complex (Ru-tmxf) as an estrogen receptor (ER) targeted photosensitizer. Ru-tmxf displays enhanced cellular uptake and PDT efficiency toward breast cancer cells with high ER expression due to the specific targeting of tamoxifen to ER and finally localizes in lysosomes. Moreover, Ru-tmxf can be activated by two-photon excitation, generating O-1(2) to damage lysosomes and result in cell death.