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个人信息Personal Information
副研究员
博士生导师
硕士生导师
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学
办公地点：大连理工大学-精细化工国家重点实验室-E330
联系方式：0411-84986257
电子邮箱：zhouhui@dlut.edu.cn
Organocatalyzed carboxylative cyclization of propargylic amides with atmospheric CO2 towards oxazolidine-2,4-diones
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论文类型：期刊论文
发表时间：2019-03-07
发表刊物：GREEN CHEMISTRY
收录刊物：SCIE
卷号：21
期号：5
页面范围：991-994
ISSN号：1463-9262
摘要：The metal-free carboxylative cyclization of propargylic amides with CO2 to oxazolidine-2,4-diones was achieved for the first time employing 1,5,7-triaza-bicyclo-[4.4.0]dec-5-ene (TBD) as an organocatalyst. This method allows for the efficient and selective synthesis of a variety of (Z) 5-alkylidene 1,3-oxazolidine-2,4-diones, and a variety of functional groups are well-tolerated under mild reaction conditions. Theoretical studies reveal that the bifunctional activity (base/H-bond donor) of TBD plays a key role in accelerating this reaction.