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Indexed by:期刊论文

Date of Publication:2019-03-27

Journal:FRONTIERS IN GENETICS

Included Journals:PubMed、SCIE

Volume:10

Page Number:233

ISSN No.:1664-8021

Key Words:anticancer drug response; autoencoder; classification model; feature selection; random forest

Abstract:Anticancer drug responses can be varied for individual patients. This difference is mainly caused by genetic reasons, like mutations and RNA expression. Thus, these genetic features are often used to construct classification models to predict the drug response. This research focuses on the feature selection issue for the classification models. Because of the vast dimensions of the feature space for predicting drug response, the autoencoder network was first built, and a subset of inputs with the important contribution was selected. Then by using the Boruta algorithm, a further small set of features was determined for the random forest, which was used to predict drug response. Two datasets, GDSC and CCLE, were used to illustrate the efficiency of the proposed method.