点击次数：

论文类型：期刊论文

发表时间：2019-03-27

发表刊物：FRONTIERS IN GENETICS

收录刊物：PubMed、SCIE

卷号：10

页面范围：233

ISSN号：1664-8021

关键字：anticancer drug response; autoencoder; classification model; feature selection; random forest

摘要：Anticancer drug responses can be varied for individual patients. This difference is mainly caused by genetic reasons, like mutations and RNA expression. Thus, these genetic features are often used to construct classification models to predict the drug response. This research focuses on the feature selection issue for the classification models. Because of the vast dimensions of the feature space for predicting drug response, the autoencoder network was first built, and a subset of inputs with the important contribution was selected. Then by using the Boruta algorithm, a further small set of features was determined for the random forest, which was used to predict drug response. Two datasets, GDSC and CCLE, were used to illustrate the efficiency of the proposed method.