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个人信息Personal Information
副教授
硕士生导师
性别：女
毕业院校：东北师范大学
学位：博士
所在单位：生物工程学院
学科：生物化学与分子生物学
办公地点：生物工程学院627室
电子邮箱：wangm@dlut.edu.cn
α-catenin SUMOylation increases IκBα stability and inhibits breast cancer progression
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论文类型：期刊论文
发表时间：2018-03-13
发表刊物：Oncogenesis
收录刊物：PubMed
卷号：7
期号：3
页面范围：28
ISSN号：2157-9024
摘要：α-catenin has been demonstrated to suppress several different types of cancers. Here we demonstrate that α-catenin is modified by SUMO protein, which covalently binds α-catenin at the carboxy terminus at lysine 870. Substitution of lysine 870 with arginine completely abolishes α-catenin SUMOylation. This modification can be removed by SENP1. However, α-catenin SUMOylation does not affect its stability and subcellular localization. In addition, we observed that the SUMOylation-deficient α-catenin mutant has a reduced interaction with IκBα which prevents subsequent ubiquitination of IκBα, and therefore a reduced suppression of expression of the NF-κB target genes TNF-α, IL-8, VEGF, and uPA. In addition, the α-catenin SUMOylation mutant shows impaired suppression of tumor growth. These results demonstrate that SUMOylation at lysine 870 of α-catenin plays a key role in the suppression of the NF-κB pathway, which inhibits breast cancer tumor growth and migration.
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