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论文类型：期刊论文

发表时间：2018-01-01

发表刊物：CANADIAN JOURNAL OF CHEMICAL ENGINEERING

收录刊物：SCIE

卷号：96

期号：1

页面范围：11-19

ISSN号：0008-4034

关键字：montmorillonite; Pickering emulsion; drug overdose; acetaminophen; detoxifying performance

摘要：Pickering emulsion stabilized with hydrophobic-modified montmorillonite (HMMT) was proposed for treating acute overdose acetaminophen intoxication, with a rapid removal rate, better stability, and good biocompatibility. The tiny HMMT was able to adsorb at the oil-water interface of the Pickering emulsion to reduce the interfacial energy along with the formation of solid particle layer, in order to enhance the stability of the emulsion and improve the removal performance. With a fast removal rate, the detoxifying Pickering emulsion removed 0.5g/L acetaminophen in the simulated gastric fluid to 0.13g/L in 6min, which is less than the intoxication content of 0.15g/L, with a leakage ratio of lower than 4% in simulated intestinal fluid over 4h. Such a detoxifying emulsion was prepared at 55 degrees C with 2% organoclay (HMMT) as the emulsifier, 6% tributyl phosphate (TBP) as the extractant, and 0.1mol/L NaOH as the inner phase in the volume ratio of 5:7. All the results denoted that the Pickering emulsion could be a promising candidate for the acute oral intoxication treatment.