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论文类型：期刊论文

发表时间：2018-01-01

发表刊物：JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY

收录刊物：SCIE、EI、Scopus

卷号：39

期号：3

页面范围：367-374

ISSN号：0193-2691

关键字：Controlled release; curcumin; hydrophobic calcium alginate; Pickering emulsion; stability

摘要：pH-responsive Pickering emulsions were prepared, taking the hydrophobic modified calcium alginate nanoparticles (MCA) of pH sensitivity as emulsifiers. The MCAs were obtained via gelation between Ca2+ in emulsion and alginate sodium that reacted with diacetone acrylamide since alginate sodium was too hydrophilic to be used as a stabilizer. The effect of MCA characteristics, Ca2+ content, and pH on the preparation and property of emulsion was evaluated. Then, the released behaviors of MCA-stabilized emulsion loading oil-soluble drug of curcumin were investigated in vitro. The results demonstrated that Pickering emulsions released curcumin intestine-specifically (37% in 4 hours with a pH of 6.8), compared with the one in the gastric fluid (3% in 4 hours with a pH of 1.5), proving that MCA had similar pH sensitivity to alginates and probably as the promising candidate in oral drug controllable release.
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