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个人信息Personal Information
副教授
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：医学部
学科：有机化学. 细胞生物学
办公地点：大连理工大学西部新校区化学综合楼C508
联系方式：Email: songting@dlut.edu.cn Tel: 18098885828
电子邮箱：songting@dlut.edu.cn
Pan-BH3 Mimetic S1 Exhibits Broad-Spectrum Antitumour Effects by Cooperation between Bax and Bak
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论文类型：期刊论文
发表时间：2013-09-01
发表刊物：BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
收录刊物：SCIE、PubMed、Scopus
卷号：113
期号：3
页面范围：145-151
ISSN号：1742-7835
摘要：Small molecule S1 is a pan-BH3 mimetic that can bind antiapoptotic Bcl-2, Bcl-xL and Mcl-1 proteins. Herein, different Bcl-2 member expression cancer cell lines (NCI-H345, MCF-7, SMMC-7721 and Hela) and cells deficient in Bax and/or Bak by shRNA were used to unravel the cascade of events by which S1 promotes apoptosis compared with Bcl-2/Bcl-xL inhibitor ABT-737. We identified that S1 exhibited broader antitumour spectrum than ABT-737 through disruption of more Bcl-2 interactions including Mcl-1/Bak interaction. Moreover, the individual and combined roles of Bax and Bak in S1-induced apoptosis were revealed. Our results showed that S1 induced a Bak-mediated apoptosis. Bak played a predominant role in either S1 or ABT-737-induced apoptosis through the cooperation with Bax on the formation of large oligomers on mitochondrial membrane.