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Indexed by:期刊论文

Date of Publication:2017-01-01

Journal:INORGANIC AND NANO-METAL CHEMISTRY

Included Journals:SCIE

Volume:47

Issue:11

Page Number:1509-1519

ISSN No.:2470-1556

Key Words:Mn(II) complex; Derivative; DNA binding; DNA damage

Abstract:The novel metal coordination polymer [Mn(L)(2)(H2O)(2)]n, was synthesized and characterized. Fluorescence and UV absorption spectroscopy indicates that the ligand and Mn(II) comploud can bind to fish sperm DNA (FS-DNA). Gel electrophoresis assay demonstrated the ability of the ligand and Mn(II) complex to cleave the HL-60 plasmid DNA. Apoptotic study shows the complexes exhibited significant cancer cell (JEKO-1 and KB) inhibitory rate. The results indicate that the complexe and the ligand bound to DNA with different binding affinity, in the order the Mn(II) complex > the ligand. Oxygen and nitrogen atoms which chelated with Mn(II) forming hydrogen bonds with N6 atom of adenine and O4 atom of thymine to affect the stability of DNA from Molecular docking study.