Release Time:2019-03-12  Hits:

Indexed by: Journal Article

Date of Publication: 2017-01-25

Journal: TETRAHEDRON LETTERS

Included Journals: Scopus、SCIE

Volume: 58

Issue: 4

Page Number: 321-325

ISSN: 0040-4039

Key Words: N-Chloramine; Chemical synthesis; Pyridinium salt; Bactericidal activity

Abstract: To develop more efficacious antibacterial agents, a new type of cationic N-chloramines that contain a pyridinium moiety and a N-chloramine moiety covalently linked via an alkyl chain were prepared and characterized. Preliminary assays indicated that 1) the compound with a propylidene linker exhibited higher antibacterial activity than the quaternary ammonium counterpart; 2) the chain length of the alkyl linker had major effects on their biocidal properties. Our results may inspire exploration of more pyridinium N-chloramines for antibacterial applications. (C) 2016 Elsevier Ltd. All rights reserved.