Study of the binding mechanism between aptamer GO18-T-d and gonyautoxin 1/4 by molecular simulation
Release Time:2019-03-13 Hits:
Indexed by: Journal Article
Date of Publication: 2016-09-14
Journal: PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Included Journals: Scopus、PubMed、SCIE
Volume: 18
Issue: 34
Page Number: 23458-23461
ISSN: 1463-9076
Abstract: GTX1/4 can induce the formation of an antiparallel G-quadruplex structure in aptamer GO18-T-d and combine steadily in the groove at the top of the G-quadruplex structure. The complex structures and special induced fit mechanism between aptamer and small molecules provide a reference for aptamer development in molecular diagnostics and therapeutic application.