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Indexed by:期刊论文

Date of Publication:2018-12-15

Journal:BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Included Journals:SCIE、PubMed、Scopus

Volume:28

Issue:23-24

Page Number:3665-3669

ISSN No.:0960-894X

Key Words:N-chlorohydantoins; Zwitterionic compounds; Chemical synthesis; Antibacterial application

Abstract:Two novel zwitterionic N-chlorohydantoin biocides, containing an N-chlorohydantoin unit and a sulfobetaine unit or a carboxybetaine unit, were chemically synthesized and characterized. Using the quaternary ammonium N-chlorohydantoin as control, the antibacterial activity of synthetic zwitterionic N-chlorohydantoins was challenged and the antibacterial data showed that carboxybetaine N-chlorohydantoin exhibited distinctively higher biocidal efficacy than QA counterpart, while sulfobetaine N-chlorohydantoin displayed slightly inferior antimicrobial efficacy. Our results may inspire further exploration of more zwitterionic N-chlorohydantoin analogs for antibacterial application.