Release Time:2019-03-13  Hits:

Indexed by: Journal Article

Date of Publication: 2018-12-15

Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Included Journals: Scopus、PubMed、SCIE

Volume: 28

Issue: 23-24

Page Number: 3665-3669

ISSN: 0960-894X

Key Words: N-chlorohydantoins; Zwitterionic compounds; Chemical synthesis; Antibacterial application

Abstract: Two novel zwitterionic N-chlorohydantoin biocides, containing an N-chlorohydantoin unit and a sulfobetaine unit or a carboxybetaine unit, were chemically synthesized and characterized. Using the quaternary ammonium N-chlorohydantoin as control, the antibacterial activity of synthetic zwitterionic N-chlorohydantoins was challenged and the antibacterial data showed that carboxybetaine N-chlorohydantoin exhibited distinctively higher biocidal efficacy than QA counterpart, while sulfobetaine N-chlorohydantoin displayed slightly inferior antimicrobial efficacy. Our results may inspire further exploration of more zwitterionic N-chlorohydantoin analogs for antibacterial application.