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Indexed by:期刊论文

Date of Publication:2014-12-01

Journal:POLYMER ENGINEERING AND SCIENCE

Included Journals:SCIE、EI、Scopus

Volume:54

Issue:12

Page Number:2902-2910

ISSN No.:0032-3888

Abstract:A fibrous scaffold is required to provide three-dimensional (3D) cell growth microenvironments and appropriate synergistic cell guidance cues. In this study, porous scaffolds with different mass ratio of poly(lactic acid) to poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB)) for tissue engineering were prepared by a modified particle leaching method. The effect of the addition of P(3HB-co-4HB) on microstructural morphology, compression property, swelling behavior, and enzymatic degradation of hybrid scaffolds was systematically investigated. The results indicated that this method was simple but efficient to prepare highly interconnected biomimetic 3D hybrid scaffolds (PP50/50 and PP33/67) with fibrous pore walls. The cytocompatibility of hybrid scaffolds was evaluated by in vitro culture of mesenchymal stem cells. The cell-cultured hybrid scaffolds presented a complete 3D porous structure, thus allowing cell proliferation on the surface and infiltration into the inner part of scaffolds. The obtained hybrid scaffolds with pore size ranging from 200 to 450 mu m, over 90% porosity, adjustable biodegradability, and water-uptake capability will be promising for cartilage tissue engineering applications. POLYM. ENG. SCI., 54:2902-2910, 2014. (c) 2014 Society of Plastics Engineers