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Indexed by:期刊论文

Date of Publication:2014-04-01

Journal:JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Included Journals:EI、PubMed、SCIE

Volume:102

Issue:4

Page Number:1121-1130

ISSN No.:1549-3296

Key Words:poly(ester-urethane)s; radiopacity; iodinated bisphenol A; biocompatibility

Abstract:Biodegradable radiopaque iodinated poly(ester-urethane) (I-PU), consisting of poly(epsilon-caprolactone) (PCL) diol and iodinated bisphenol A (IBPA), has been successfully synthesized via a coupling reaction of PCL-diisocyanate and IBPA with varying compositions. The IBPA with four iodine atoms per molecule was applied as a chain extender to endow the I-PUs with intrinsic X-ray visibility. The chemical structure and molecular weights of I-PUs were characterized by Fourier transform infrared spectroscopy (FT-IR), proton-nuclear magnetic resonance, and gel permeation chromatography (GPC). The effects of IBPA on the physical properties of I-PUs were systematically studied by means of differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and wide-angle X-ray diffraction (WAXD). The DSC results showed that the crystallization of PCL segments in I-PUs was restrained with increasing amount of IBPA, which was also confirmed by WAXD. In the X-radiography analysis, all the synthesized I-PUs exhibited high radiopacity compared with an aluminum wedge of equivalent thickness. Enzymatic degradation tests showed that the incorporation of IBPA prolonged the degradation of I-PUs and distinct mass loss and degradation happened in the third month. Basic cytocompatibility conducted using rat adipose-derived cells proved that all the I-PUs and their biodegradation products were nontoxic. The radiopaque I-PUs is expected to possess a significant advantage over the traditional polymer counterparts in some related biomedical fields. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1121-1130, 2014.