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论文类型：期刊论文

发表时间：2013-08-01

发表刊物：CHINESE JOURNAL OF CANCER RESEARCH

收录刊物：SCIE、PubMed、ISTIC

卷号：25

期号：4

页面范围：442-450

ISSN号：1000-9604

关键字：Circadian rhythm; breast cancer; circadian proteins; chronotherapy

摘要：The circadian rhythm is an endogenous time keeping system shared by most organisms. The circadian clock is comprised of both peripheral oscillators in most organ tissues of the body and a central pacemaker located in the suprachiasmatic nucleus (SCN) of the central nervous system. The circadian rhythm is crucial in maintaining the normal physiology of the organism including, but not limited to, cell proliferation, cell cycle progression, and cellular metabolism; whereas disruption of the circadian rhythm is closely related to multi-tumorigenesis. In the past several years, studies from different fields have revealed that the genetic or functional disruption of the molecular circadian rhythm has been found in various cancers, such as breast, prostate, and ovarian. In this review, we will investigate and present an overview of the current research on the influence of circadian rhythm regulating proteins on breast cancer.