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博士生导师

硕士生导师

性别:男

毕业院校:德国马普高分子所

学位:博士

所在单位:化工学院

办公地点:大连理工大学西部校区E-226

联系方式:sunwen@dlut.edu.cn

电子邮箱:sunwen@dlut.edu.cn

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Construction of Long-Wavelength Fluorescein Analogues and Their Application as Fluorescent Probes

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论文类型:期刊论文

发表时间:2013-05-01

发表刊物:CHEMISTRY-A EUROPEAN JOURNAL

收录刊物:SCIE、EI、PubMed、Scopus

卷号:19

期号:21

页面范围:6538-6545

ISSN号:0947-6539

关键字:colorimetric analysis; fluorescence; fluorescent probes; mitochondria; thiol probes; imaging

摘要:Born to dye: Five fluorescein analogues were synthesised (see scheme). One analogue was found to emit in the NIR region with a high quantum yield, excellent photostability and good permeability. Three derivatives were found to specifically stain mitochondria and one dye responds to thiols with a strong turn-on NIR fluorescence signal and colorimetric change, in vitro and in vivo.Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.