Tumor Acidic Microenvironment Targeted Pyropheophorbide a Dimer, an Alternative Strategy for Simultaneous Tumor Fluorescence Imaging and PDT Treatment
Release Time:2019-11-01 Hits:
Indexed by: Journal Papers
Date of Publication: 2019-01-01
Journal: MACROHETEROCYCLES
Included Journals: SCIE
Volume: 12
Issue: 2
Page Number: 187-192
ISSN: 1998-9539
Key Words: Pyropheophorbide a; dimer; FRET; cis-aconitic anhydride; phototoxicity; PDT
Abstract: Targeting tumor acidic microenvironment, a cis-aconitate linked pyropheophorbide a dimer 3 was designed and prepared The observed fluorescence quenching of 3 verified our FRET based molecular design. Acid-dependent cleavage in aqueous solution, singlet oxygen generation, and cytotoxiciry against HepG2 cell lines of dimer 3 were investigated. The dimer demonstrated different levels of fluorescence recovery when incubated in acidic aqueous environment as well as effective phototoxicity against HepG2 cells.
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