Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2014-08-01

Journal: PLANTA MEDICA

Included Journals: Scopus、PubMed、SCIE

Volume: 80

Issue: 13

Page Number: 1124-1130

ISSN: 0032-0943

Key Words: Scopolia tangutica; Solanaceae; alkaloid; hydroxycinnamic acid amide; mu-opioid receptor

Abstract: Four new hydroxycinnamic acid amides, scotanamines A-D (1-4), and seven known alkaloids, including N-1,N-10-di-dihydrocaffeoylspermidine (5), scopolamine (6), anisodamine (7), hyoscyamine (8), anisodine (9), caffeoylputrescine (10), and N-1-caffeoyl-N-3-dihydrocaffeoylspermidine (11), were obtained from the roots of Scopolia tangutica. The present study represents the first recognition of hydroxycinnamic acid amides containing putrescine or spermidine in S. tangutica. Compound 1, in particular, contains a moiety resulting from the condensation of nortropinone and putrescine. Compound 2 exhibited moderate agonist activity at the mu-opioid receptor (EC50 = 7.3 mu M). Compound 2 was tested in vivo and induced analgesia in mice. The analgesic effect was recorded using the tail-flick assay and was reversed by naloxone.