|
个人信息Personal Information
教授
博士生导师
硕士生导师
任职 : 精细化工全国重点实验室主任，教育部智能材料化工前沿科学中心执行主任，大连理工大学膜科学与技术研究开发中心主任
性别：女
毕业院校：中国科学院大连化物所
学位：博士
所在单位：化工学院
学科：化学工程. 膜科学与技术. 生物医学工程
联系方式：hgaohong@dlut.edu.cn
电子邮箱：hgaohong@dlut.edu.cn
Preparation and in vitro evaluation of hydrophobic-modified montmorillonite stabilized pickering emulsion for overdose acetaminophen removal
点击次数：
论文类型：期刊论文
发表时间：2018-01-01
发表刊物：CANADIAN JOURNAL OF CHEMICAL ENGINEERING
收录刊物：SCIE
卷号：96
期号：1
页面范围：11-19
ISSN号：0008-4034
关键字：montmorillonite; Pickering emulsion; drug overdose; acetaminophen; detoxifying performance
摘要：Pickering emulsion stabilized with hydrophobic-modified montmorillonite (HMMT) was proposed for treating acute overdose acetaminophen intoxication, with a rapid removal rate, better stability, and good biocompatibility. The tiny HMMT was able to adsorb at the oil-water interface of the Pickering emulsion to reduce the interfacial energy along with the formation of solid particle layer, in order to enhance the stability of the emulsion and improve the removal performance. With a fast removal rate, the detoxifying Pickering emulsion removed 0.5g/L acetaminophen in the simulated gastric fluid to 0.13g/L in 6min, which is less than the intoxication content of 0.15g/L, with a leakage ratio of lower than 4% in simulated intestinal fluid over 4h. Such a detoxifying emulsion was prepared at 55 degrees C with 2% organoclay (HMMT) as the emulsifier, 6% tributyl phosphate (TBP) as the extractant, and 0.1mol/L NaOH as the inner phase in the volume ratio of 5:7. All the results denoted that the Pickering emulsion could be a promising candidate for the acute oral intoxication treatment.