大连理工大学主页平台管理系统王华楠 Bone-on-a-chip recapitulates dynamic bone remodeling 王华楠

论文成果

Entanglement-Driven Adhesion, Self-Healing, and High Stretchability of Double-Network PEG-Based Hydrogels: 点击次数：; 发布时间： 2019-11-07; 发布时间：2019-11-07; 论文类型：期刊论文; 发表时间：2019-10-09; 发表刊物：ACS APPLIED MATERIALS & INTERFACES; 收录刊物：SCIE、PubMed; 卷号：11; 期号：40; 页面范围：36458-36468; ISSN号：1944-8244; 关键字：tissue adhesives; double network; self-healing; entanglement effect; polyethylene glycol (PEG); 摘要：Hydrogels that are capable of wet adhesion and self-healing can enable major advances in a variety of biomedical applications such as tissue regeneration, wound dressings, wearable/implantable devices, and drug delivery. We hereby developed an innovative but simple strategy to achieve adhesive, self-healing, and highly stretchable double-network hydrogels, which were composed of a primary covalent polyethylene glycol diacrylate (PEGDA) network in combination with a noncovalent network of highly diffusive, giant PEG chains. The adhesion to substrates including tissue matrices was instant and repeatable due to the diffusive PEG chains that can spontaneously penetrate and entangle with the substrate network. Combining the intrinsic biocompatibility of PEG and rational design for tuning the hydrogel network properties, we exemplarily demonstrated that this hydrogen can be used as a three-dimensional matrix for cell culture or as a tissue adhesive for wound healing. The in vivo study showed that the hydrogel is capable of effectively triggering skin wound healing with a significantly lower immune response in comparison to commercial tissue adhesives currently used in clinics. Therefore, our study provides new and critical insights into the design strategy to achieve adhesion and rehealability by taking advantages of the entanglement effect from double-network hydrogels and opens up a new avenue for the application of entanglement-driven hydrogels in regenerative medicine.

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王华楠

同专业博导同专业硕导个人学术主页

教授博士生导师硕士生导师

性别：男

毕业院校：Radboud大学奈美根医学院

学位：博士

所在单位：生物工程学院

学科：生物化工. 生物工程与技术. 高分子材料

办公地点：生物工程学院525

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