Research Field

Aziz ur Rehman Aziz, Xiaohui Yu, Qingyun Jiang, Youyi Zhao, Sha Deng, Kairong Qin, Hanqin Wang*, Bo Liu*. Doxorubicin-induced toxicity to 3D-cultured rat ovarian follicles on a microfluidic chip. Toxicology in Vitro. TIV_104677. Accepted

Wei Juan, Liu Chong, Jiang Yang, Duan Chunzheng, Chen Li, Li Wang, Liu Bo*, Li Jingmin* , Microfluidic device for generating regionalized concentration gradients under a stable and uniform fluid microenvironment. Journal of Micromechanics & Microengineering. 2019;29(1): 015008

Baohong Zhang, Fei Xie, Aziz ur Rehman Aziz , Shuai Shao, Wang Li, Sha Deng, Xiaoling Liao, Bo Liu*.Heat Shock Protein 27 Phosphorylation Regulates Tumor Cell Migration under Shear Stress. Biomolecules. 2019, 9, 50; doi:10.3390/biom9020050

Aziz ur Rehman Aziz, Chunyang Geng, Wang Li, Xiaohui Yu, Kai-Rong Qin, Hanqin Wang*, Bo Liu*. Doxorubicin induces ER calcium release via Src in rat ovarian follicles. Toxicological Sciences. 2019, 168（1）：171-178. doi: 10.1093/toxsci/kfy284  (毒理学领域Top杂志)

Shuai Shao^†, Xiaoling Liao^†, Fei Xie, Sha Deng, Xue Liu, Tapani Ristaniemi, Bo Liu*. FRET biosensor allows spatio-temporal observation of shear stress-induced polar RhoGDIα activation. Communications Biology, 2018, COMMSBIO-17-0229C. Accepted  (Nature系列杂志)

Fei Xie; Baohong Zhang; Wenfeng Xu; Xiaoling Liao*; Qiuhong Huang; Bo Liu*.  Membrane fluidity regulates high shear stress-induced FAK activation at different subcellular compartments. Biocell. 2018, 41(2-3): 45-53

Wang Li, Xinlei Yu, Fei Xie, Baohong Zhang, Shuai Shao, Chunyang Geng, Aziz ur Rehman Aziz, Xiaoling Liao, Bo Liu*. A membrane-bound biosensor visualizes shear stress-induced inhomogeneous alteration of cell membrane tension. iScience, 2018, 7:180-190. DOI:10.1016/j.isci.2018.09.002（Cell系列杂志）

Geng C⁺, Li C⁺, Li W, Yan W, Li J, Aziz A U R, Zhai X, Sun W*, Liu B*. A Simple Fabricated Microfluidic Chip for Urine Sample-based Bladder Cancer Detection. Journal of Micromechanics & Microengineering, 2018, 28: 115011. doi: 10.1088/1361-6439/aae016 

 Aziz ur Rehman Aziz, Sumbal Farid, Kairong Qin, Hanqin Wang*, Bo Liu*. Regulation of insulin resistance and glucose metabolism by interaction of PIM kinases and insulin receptor substrates. Archives of Physiology and Biochemistry.  2018. DOI: 10.1080/13813455. 2018. 1498903 

Chen ZZ, Yuan WM, Xiang C, Zeng DP, Liu B, Qin KR. A microfluidic device with spatiotemporal wall shear stress and ATP signals to investigate the intracellular calcium dynamics in vascular endothelial cells. Biomech Model Mechanobiol. 2018 Sep 6. doi: 10.1007/s10237-018-1076-x

Wang Li, Chunyang Gen, Bo Liu*. Visualization of synaptic vesicle dynamics with fluorescence proteins. Folia Neuropathologica, 2018; 56 (1): 21-29. DOI: 10.5114/fn.2018.74656

Wei Juan, Liu Chong, Jiang Yang, Liu Tao, Chen Li, Liu Bo*, Li Jingmin*. Uniform and stable supply of medium for in-vitro cell culture using a robust chamber. Journal of Micromechanics and Microengineering. 2018.  28(6) ：065006· DOI: 10.1088/1361-6439/aab374

Aziz Ur Rehman Aziz, Sumbal farid, Kai-Rong Qin, Hanqin Wang*, Bo Liu*. PIM kinases and its relevance to the PI3K/AKT/mTOR pathway in regulation of ovarian cancer. Biomolecules. 2018, 8(1): 7; doi:10.3390/biom8010007

Chiyu Li, Wang Li, Chunyang Geng, Haijun Ren, Xiaohui Yu, Bo Liu*. Microfludic chip for cancer cell detection and diagnosis. Journal of Mechanics in Medicine and Biology. 2018, 18(1): 1830001. DOI: 10.1142/S0219519418300016

Shuai Shao, Cheng Xiang, Kairong Qin, Aziz ur Rehman Aziz, Xiaoling Liao, Bo Liu*. Visualizing the spatiotemporal map of Rac activation in bovine aortic endothelial cells under laminar and disturbed flows. PLOS ONE. 2017 Nov 30;12(11):e0189088. doi: 10.1371/journal.pone.0189088

 Aziz Ur Rehman Aziz†, Mengjie Fu†, Jiu Deng, Chunyang Geng, Yong Luo, Bingcheng Lin, Xiaohui Yu*, and Bo Liu*, A Microfluidic Device for Culturing an Encapsulated Ovarian Follicle. Micromachines. 2017, 8(11), 335; doi:10.3390/mi8110335

Jingmin Li, Juan Wei, Yuanchang Liu, Bo Liu, Tao Liu, Yang Jiang, Laiqian Ding and Chong Liu. A microfluidic design to provide a stable and uniform in vitro microenvironment for cell culture inspired by the redundancy characteristic of leaf areoles. Lab on a Chip. 2017, 17, 3921–3933

Aziz Ur Rehman Aziz, Chunyang Geng, Mengjie Fu , Xiaohui Yu, Kairong Qin and Bo Liu*. The Role of Microfluidics for Organ on Chip Simulations. Bioengineering. 2017, 4(2), 39; doi:10.3390/ bioengineering4020039. 

Fei Xie, Shuai Shao, Aziz ur Rehman Aziz, Baohong Zhang, Hanqin Wang, Bo Liu*. Role of Rho-specific guanine nucleotide dissociation inhibitor α regulation in cell migration. Acta Histochemica.  2017, 119 (3) :183 

Zongzheng CHEN, Weimo YUAN, A. R. AZIZ, Zhengming GAO, Depei ZENG, Bo LIU, Kairong QIN. Transfer characteristics of dynamic biochemical signals in non-reversing pulsatile flows in a shallow Y-shaped microfluidic channel: signal filtering and nonlinear amplitude-frequency modulation. Appl. Math. Mech. -Engl. Ed., 2017, 38(10):1481–1496 DOI 10.1007/s10483-017-2251-6

Chen ZZ, Gao ZM, Zeng DP, Liu B, Luan Y, Qin KR. A Y-shaped microfluidic device to study the combined effect of wall shear stress and ATP signals on intracellular calcium dynamics in vascular endothelial cells, Micromachines, 2016, 7(11), 213, doi:10.3390/mi7110213

Yu M, Chen ZZ, Xiang C, Liu B, Xie HD, Qin KR. Microfluidic-based single cell trapping using a combination of stagnation point flow and physical barrier, Acta Mechanica Sinica, 2016, 32(3), 422-429, doi:10.1007/s10409-016-0558-2

Wenfeng Xu#, Bo Liu(Co-first author), Xue Liu, Jie Xu, Bo Li, Xiaoling Liao* .Regulation of BMP2-induced intracellular calcium increases in osteoblasts. Journal of Orthopaedic Research. 2016. 34(10):1725-1733. JOR-15-0392.R2(23196)（骨科学Top杂志）

Wang YX, Xiang C, Liu B, Zhu Y, Luan Y, Liu ST, Qin KR. A multi-component parallel-plate flow chamber system for studying the effect of exercise-induced wall shear stress on endothelial cells. Biomed Eng Online. 2016. 28;15(Suppl 2):154. doi: 10.1186/s12938-016-0273-z.

Han Y, Wang L, Yao QP, Zhang P, Liu B, Wang GL, Shen BR, Cheng B, Wang Y, Jiang ZL, Qi YX. Nuclear envelope proteins Nesprin2 and LaminA regulate proliferation and apoptosis of vascular endothelial cells in response to shear stress. Biochim Biophys Acta. 2015;1853(5):1165-73. doi: 10.1016/j.bbamcr. 2015.02.013.

 Liu, B. Shaoying Lu, Ying-li Hu, Xiaoling Liao, Mingxing Ouyang, Yingxiao Wang. RhoA and Membrane Fluidity Mediates the Spatially Polarized Src/FAK Activation in Response to Shear Stress. Scientific Reports. 2014；4：7008; DOI:10.1038/srep07008

Jie Sun,Shaoying Lu,Mingxing Ouyang,Li-Jung Lin,Yue Zhuo,Bo Liu,Shu Chien, Benjamin G. Neel& Yingxiao Wang.Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2. Nature Communications. 2013；4 (3) :2037  doi:10.1038 

Wenfeng Xu, Xiaoling Liao, Ling Zhang, and Bo Liu*. Tissue Induction, the Relationship between Biomaterial’s Microenvironment and Mesenchymal Stem Cell Differentiation. Journal of Biomedical Science and Engineering, 2013；6(1):85-91