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论文类型：期刊论文

发表时间：2017-07-01

发表刊物：ADVANCED SCIENCE

收录刊物：SCIE、PubMed、Scopus

卷号：4

期号：7

页面范围：1700113

ISSN号：2198-3844

关键字：cancer; photodynamic therapy; photosensitization; singlet oxygen

摘要：With singlet oxygen (O-1(2)) as the active agent, photodynamic therapy (PDT) is a promising technique for the treatment of various tumors and cancers. But it is hampered by the poor selectivity of most traditional photosensitizers (PS). In this review, we present a summary of controllable PDT implemented by regulating singlet oxygen efficiency. Herein, various controllable PDT strategies based on different initiating conditions (such as pH, light, H2O2 and so on) have been summarized and introduced. More importantly, the action mechanisms of controllable PDT strategies, such as photoinduced electron transfer (PET), fluorescence resonance energy transfer (FRET), intramolecular charge transfer (ICT) and some physical/chemical means (e.g. captivity and release), are described as a key point in the article. This review provide a general overview of designing novel PS or strategies for effective and controllable PDT.