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论文类型：期刊论文

发表时间：2016-11-09

发表刊物：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录刊物：SCIE、EI、PubMed、ESI高被引论文、Scopus

卷号：138

期号：44

页面范围：14586-14591

ISSN号：0002-7863

摘要：Tissue penetration depth is a major challenge in practical photodynamic therapy (PDT). A biocompatible and highly effective near infrared (NIR)-light-absorbing carbazole-substituted BODIPY (Car-BDP) molecule is reported as a class of imaging guidable deep-tissue activatable photosensitizers for PDT. Car-BDP possesses an intense, broad NLR. absorption band (600-800 nm) with a remarkably high singlet oxygen quantum yield (Phi(Delta) = 67%). After being encapsulated with biodegradable PLA-PEG-FA polymers, Car-BDP can form uniform and small organic nano particles that are water-soluble and tumor-targetable. Rather than using laser light, such nanoparticles offer an unprecedented deep-tissue, tumor targeting photodynamic therapeutic effect by using an exceptionally low-power-density and cost-effective lamp light (12 mW cm(-2)). In addition, these nanoparticles can be simultaneously traced in vivo due to their excellent NIR fluorescence. This study signals a major step forward in photodynamic therapy by developing a new class of NIR-absorbing biocompatible organic nanoparticles for effective targeting and treatment of deep-tissue tumors. This work also provides a potential new platform for precise tumor-targeting theranostics and novel opportunities for future affordable clinical cancer treatment.