张文珠简介

Ø  个人经历

大连理工大学化学学院教授，硕士生、博士生导师

中国科学院兰州化学物理研究所，分析化学专业，博士

兰州大学，分析化学专业，本科

Ø  研究方向

    围绕疾病早期诊断中具有重要生理作用分子的识别与检测，聚焦活体内原位、实时、在线荧光成像研究中的关键科学问题，构建了过渡金属配合物发光探针检测平台，用于血液、细胞、小动物等样品生物成像分析以及相关疾病诊断治疗研究。主持国家自然科学基金项目3项，作为骨干力量参加863课题、国家自然科学基金重点项目等多项课题。在光致发光-电致化学发光双信号响应探针；细胞器靶向特异性识别生理活性小分子探针；时间分辨模式长寿命发光探针等研究工作中取得了一系列的研究成果。近年来以通讯作者/第一作者身份在J. Am. Chem. Soc. (化学类顶刊，ESI高被引), Angew. Chem. Int. Ed. (化学类顶刊), Chem. Eng. J., Adv. Sci., Biomaterials, Biosens. Bioelectron. (ESI高被引), Anal. Chem., Sensor. Actuat. B-Chem., Chem. Commun., Chem. Eur. J., Inorg. Chem., Anal. Chim. Acta, Talanta, Dalton Trans., Analyst等国际知名学术刊物发表论文。授权发明专利2项。培养研究生获得国家奖学金、优秀论文、单项奖学金和优秀研究生标兵（每年全校博士生4人，校研究生最高奖项）等荣誉。指导本科生获得国家级、省级、校级大学生化学新实验设计赛一等奖、二等奖；国家级、省级、校级大创项目多项。

Ø  代表性论文（通讯作者/第一作者）：

1.     Xiaona Gao; Wenzhu Zhang*; Zhiyuan Dong; Junyu Ren; Jiacheng Wang; Bo Song; Xiaoyang Liu*; Jingli Yuan*. Multichannel, Multifunctional Ruthenium(II) Complex Luminescent Probe for Elucidating the Relationship between Peroxynitrite, Ferroptosis, and Parkinson’s Disease. Sensor. Actuat. B-Chem. 2025, 428, 137264.

2.     Jiacheng Wang; Xiaona Gao; Junyu Ren; Bo Song; Wenzhu Zhang*; Jingli Yuan*. A Novel Ratiometric Luminescent Probe Based on a Ruthenium(II) Complex-Rhodamine Scaffold for ATP Detection in Cancer Cells. Talanta 2025, 286, 127538.

3.     Qianqian Fa; Xiaona Gao; Wenzhu Zhang*; Junyu Ren; Bo Song; Jingli Yuan*. Tracking Plasma Membrane Damage Using a Ruthenium(II) Complex Phosphorescent Indicator Paired with Cholesterol. Inorg. Chem. 2024, 63, 10443−10451.

4.     Yetong Gao; Wenzhu Zhang*; Bo Song; Xiangyu Meng; Jingli Yuan*. A Novel Iridium(III) Complex-Based Ratiometric Luminescence Probe for Monitoring Hydrogen Sulfide in Living Cells and Zebrafish. Talanta 2024, 274, 125982.

5.     Junyu Ren; Wenzhu Zhang*; Xiaona Gao; Bo Song; Jingli Yuan*. Unveiling the Negative Correlation of Formaldehyde and Hydrogen Sulfide in Parkinson’s Disease Models Using a Dual-Responsive Ruthenium(II) Complex Probe. Chem. Eng. J. 2024, 486, 150349.

6.     Xiaona Gao; Wenzhu Zhang*; Zhiyuan Dong; Junyu Ren; Bo Song; Run Zhang*; Jingli Yuan*. FRET Luminescent Probe for the Ratiometric Imaging of Peroxynitrite in Rat Brain Models of Epilepsy-Based on Organic Dye-Conjugated Iridium(III) Complex. Anal. Chem. 2023, 95, 18530−18539.

7.     Junyu Ren; Zhongbo Du; Wenzhu Zhang*; Run Zhang; Bo Song; Jingli Yuan*. Development of a Fluorescein Modified Ruthenium(II) Complex Probe for Lysosome-Targeted Ratiometric Luminescence Detection and Imaging of Peroxynitrite in Living Cells. Anal. Chim. Acta. 2022, 1205, 339784.

8.     Chaolong Liu; Wenzhu Zhang*; Run Zhang; Xiaona Gao; Bo Song; Jingli Yuan. Ruthenium(II) Complex-Based Long-Lived Two-Photon Luminescence Probe for Dynamic Monitoring of Glutathione S-Transferases in Mouse Models of Drug-Induced Liver Injury. Sensor. Actuat. B-Chem. 2022, 357, 131440.

9.     Chaolong Liu; Jianping Liu; Wenzhu Zhang*; Yong-Lei Wang; Qi Liu; Bo Song; Jingli Yuan*; Run Zhang*. “Two Birds with One Stone” Ruthenium(II) Complex Probe for Biothiols Discrimination and Detection in Vitro and in Vivo. Adv. Sci. 2020, 7, 2000458.

10.   Wenzhu Zhang*; Xiuyan Xi; Yong-Lei Wang; Zhongbo Du; Chaolong Liu; Jianping Liu; Bo Song; Jingli Yuan*; Run Zhang*. Responsive Ruthenium Complex Probe for Phosphorescence and Time - Gated Luminescence Detection of Bisulfite. Dalton Trans. 2020, 49, 5531−5538.

11.   Chaolong Liu; Run Zhang*; Wenzhu Zhang*; Jianping Liu; Yong-Lei Wang; Zhongbo Du; Bo Song; Zhi Ping Xu; Jingli Yuan*. “Dual-Key-and-Lock” Ruthenium Complex Probe for Lysosomal Formaldehyde in Cancer Cells and Tumors. J. Am. Chem. Soc. 2019, 141, 8462 - 8472. (ESI 高被引)

12.   Zhongbo Du; Run Zhang*; Bo Song; Wenzhu Zhang*; Yong-Lei Wang; Jianping Liu; Chaolong Liu; Zhiping Xu; Jingli Yuan*. Iridium(III) Complex-Based Activatable Probe for Phosphorescent/Time-Gated Luminescent Sensing and Imaging of Cysteine in Mitochondria of Live Cells and Animals. Chem. Eur. J. 2018, 24, 1498 - 1506. (封面)

13.   Wenzhu Zhang*; Yi Liu; Quankun Gao; Chaolong Liu; Bo Song; Run Zhang*; Jingli Yuan*. A Ruthenium(II) Complex-Cyanine Energy Transfer Scaffold Based Luminescence Probe for Ratiometric Detection and Imaging of Mitochondrial Peroxynitrite. Chem. Commun. 2018, 54, 13698−13701.

14.   Zhongbo Du; Bo Song; Wenzhu Zhang*; Chengchen Duan; Yong-Lei Wang; Chaolong Liu; Run Zhang*; Jingli Yuan*. Quantitative Monitoring and Visualization of Hydrogen Sulfide in Vivo Using a Luminescent Probe Based on a Ruthenium(II) Complex. Angew. Chem. Int. Ed. 2018, 57, 3999−4004.

15.   Wenzhu Zhang*; Feiyue Zhang; Yong-Lei Wang; Bo Song; Run Zhang*; Jingli Yuan. Red - Emitting Ruthenium(II) and Iridium(III) Complexes as Phosphorescent Probes for Methylglyoxal in Vitro and in Vivo. Inorg. Chem. 2017, 56, 1309−1318.

16.   Feiyue Zhang; Xiaowen Liang; Wenzhu Zhang*; Yong-Lei Wang; Haolu Wang; Yousuf H. Mohammed; Bo Song; Run Zhang*; Jingli Yuan. A Unique Iridium(III) Complex-Based Chemosensor for Multi-Signal Detection and Multi-Channel Imaging of Hypochlorous Acid in Liver Injury. Biosens. Bioelectron. 2017, 87, 1005−1011. (ESI 高被引)

17.   Liyan Cao; Run Zhang; Wenzhu Zhang*; Zhongbo Du; Chunjun Liu; Zhiqiang Ye; Bo Song; Jingli Yuan*. A Ruthenium(II) Complex-Based Lysosome-Targetable Multisignal Chemosensor for in Vivo Detection of Hypochlorous Acid. Biomaterials. 2015, 68, 21− 31.

所在课题组由本科生、硕士研究生、博士研究生和博士后组成，研究团队相互协作、积极进取。热诚邀请踏实努力、喜欢本研究方向的同学加入到我们的队伍！课题组将为同学们提供多方面锻炼和成长的机会！

联系方式：0411-84063807（长期有效），wzhzhang@dlut.edu.cn