Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2015-01-01

Journal: CHINESE CHEMICAL LETTERS

Included Journals: CSCD、ISTIC、SCIE

Volume: 26

Issue: 1

Page Number: 55-57

ISSN: 1001-8417

Key Words: Pyridine N-oxides; Arylation; Palladium; Suzuki reaction; Water

Abstract: We report a practical and highly efficient protocol for the arylation of pyridine N-oxides with arylboronic acid through palladium-catalyzed Suzuki reaction in water. This ligand-free Suzuki reaction is performed in the presence of diisopropylamine and gives 2- or 3-arylated pyridyl N-oxide derivatives in good to excellent yields within 1 h. (C) 2014 Chun Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. All rights reserved.